In 2019, Denver became the first city in the United States to decriminalize psilocybin, kicking off a wave of psychedelic policy reform throughout the nation. Now in 2026, natural medicines are decriminalized statewide, and Colorado officials are preparing to roll out a regulated program for their facilitated use. PsyCon is the premier trade show and expo for Colorado’s emerging psychedelic industry. Featuring the top names in psychedelic science presenting the latest cutting-edge research, PsyCon offers entrepreneurs and consumers alike the chance to learn, network, and build the foundation for what could soon be one of the biggest psychedelic markets in the nation.